Non-pharmacological modulation of cerebral white matter integrity: a systematic review.
Poster B53, Friday, October 21, 11:30 am - 1:00 pm, Le Baron
tina dam kristensen1,2,3, Rene Mandl2,6, Jens Richardt M. Jepsen2,5, Egill Rostrup4, Louise B. Glenthoej1,2,3, Merete Nordentoft1,2,3, Birte Glenthoej2,3, Bjørn H. Ebdrup2; 1Mental Health Centre Copenhagen, University of Copenhagen, DK-2900, Hellerup, Denmark,, 2Centre for Neuropsychiatric Schizophrenia Research (CNSR) & Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, DK-2600 Glostrup, Denmark, 3Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, 4Functional Imaging Unit, Department of Diagnostics, Rigshospitalet, University of Copenhagen, DK-2600 Glostrup, 5Child and Adolescent Mental Health Centre, Mental Health Services Capital Region of Denmark, University of Copenhagen, 6Neuroimaging Research Group, University Medical Center Utrecht, Nl
Background: Studies using functional magnetic resonance imaging have provided increasing evidence that specified training regimens can affect functional cerebral connectivity. To what extend active training regimens can alter structural connectivity is not clear. The purpose of this review is to summarize the evidence and discuss the relevance of using cerebral white matter organization as a biological outcome measure in non-pharmacological psychiatric intervention studies. Methods: Prospective registration of the review has been submitted to PROSPERO (Reg.No. CRD42016038639). Study search is performed in accordance with PRISMA-guidelines in the electronic databases PubMed and EMBASE. Longitudinal intervention studies published in peer-reviewed journals, with human participants aged 18-60 years are included. Interventions must be non-pharmacological, and any type of active training regimens will be included. Duration of interventions is between 1 day and 1 year. Randomized, controlled trials (RCTs); controlled clinical trials (CCTs) and controlled before-after (CBA) studies are included. The primary outcome is task-associated significant changes in cerebral white matter organization, as measured from baseline to follow-up with diffusion-weighted imaging parameters. We systematically assess risk of bias in RCTs according to the recommended approach for assessing risk of bias in Cochrane reviews, and for CCTs using the Newcastle-Ottawa Scale (NOS). Results Database search delivered 2037 hits. 19 eligible studies have been identified. Final results will be presented at the conference, including characteristics of subjects, studies, interventions, MRI-methodology, outcomes and risk of bias.
Topic Area: Neuroimaging